Phosphatidylinositol transfer proteins: an essential requirement in inositol lipid signalling.
نویسندگان
چکیده
of Biochemistry, University of Dundee) and L. A. J. O'Neill (Department of Biochemistry, Trinity College Dublin), Edited by C. P. Downes and Sponsored by Pro Yamanouchi Research Institute; Scottish Enterprise, Tayside; Merck, Sharp and Dohme; McKay and Lynn; SmithKline Beecham; Pfizer Ltd.; British Biotech Pharmaceuticals Ltd.; and Dundee City Council and Tourist Board. 662nd Meeting held at the University of Dundee, 20-3 I July, 1997.
منابع مشابه
A review on the role of inositol in aquaculture
Inositol is usually classified as an essential vitamin for most animals, and is recognised as a part of the B-complex vitamins. Among all other inositol isomer forms, myo-inositol possesses biological activity. It is found in the brain, skeletal, heart, and main reproductive tissues and exists as a structural component of phosphatidylinositol in biological cell membranes. Myo-inositol, also act...
متن کاملA review on the role of inositol in aquaculture
Inositol is usually classified as an essential vitamin for most animals, and is recognised as a part of the B-complex vitamins. Among all other inositol isomer forms, myo-inositol possesses biological activity. It is found in the brain, skeletal, heart, and main reproductive tissues and exists as a structural component of phosphatidylinositol in biological cell membranes. Myo-inositol, also act...
متن کاملPhosphatidylinositol transfer protein dictates the rate of inositol trisphosphate production by promoting the synthesis of PIP2
BACKGROUND Phosphatidylinositol transfer protein (PI-TP), which has the ability to transfer phosphatidylinositol (PI) from one membrane compartment to another, is required in the inositol lipid signalling pathway through phospholipase C-beta (PLC-beta) that is regulated by GTP-binding protein(s) in response to extracellular signals. Here, we test the hypothesis that the principal role of PI-TP ...
متن کاملTrafficking of phosphatidylinositol by phosphatidylinositol transfer proteins.
PtdIns is synthesized at the endoplasmic reticulum and its intracellular distribution to other organelles can be facilitated by lipid transfer proteins [PITPs (phosphatidylinositol transfer proteins)]. In this review, I summarize the current understanding of how PITPs are regulated by phosphorylation, how can they dock to membranes to exchange their lipid cargo and how cells use PITPs in signal...
متن کاملDynamics of Lipid Transfer by Phosphatidylinositol Transfer Proteins in Cells
Of many lipid transfer proteins identified, all have been implicated in essential cellular processes, but the activity of none has been demonstrated in intact cells. Among these, phosphatidylinositol transfer proteins (PITP) are of particular interest as they can bind to and transfer phosphatidylinositol (PtdIns)--the precursor of important signalling molecules, phosphoinositides--and because t...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 25 4 شماره
صفحات -
تاریخ انتشار 1997